张海元，中国科学院长春应用化学研究所研究员、博士生导师。2005年毕业于中国科学院长春应用化学研究所并获博士学位，2005至2013年期间先后在美国Wayne State University、Rensselaer Polytechnic Institute和University of California，Los Angeles从事科研工作。2014年至今就职于中国科学院长春应用化学研究所，2015年入选中科院人才计划。先后主持和参与科技部重点研发计划项目、基金委国家自然科学基金项目及吉林省科技厅医药重点研发项目。兼职《Materials》和《Nanoscience and Nanotechnology》等杂志编委、中国毒理学会纳米毒理学专业委员会委员、中国生物物理学会材料生物学与智能诊疗技术分会委员会委员和国际纳米光电子学与生物光电子学联合中心学术委员会委员。
多年来致力于光电子活性纳米体系的生物医学应用研究，着重于通过精确调控纳米体系的能级电子结构，在纳米生物界面水平考察纳米体系与生物系统之间的电子传递和能量转化，深入理解纳米体系介导下的生物信号响应进程，促进多种生物医学功能的完善与革新，实现了疾病的诊断与治疗。研究成果先后发表于Advanced Materials、Angewandte Chemie International Edition、Journal of the American Chemical Society和Account Chemical Research等国际顶级学术期刊80余篇，授权发明专利8项，受邀参加国内外学术会议并做大会报告和特邀报告20余次，研究成果被C&EN、AZoNano和Nanowerk等科技媒体醒目报道和重点推送，指导的研究生先后两次获中科大光华奖学金。
研究领域：
纳米生物医用材料
智能药物的靶向递送与时空控释
安全性纳米材料
代表性论著：
Yan, J.; Wang, Y.J.; Mu, Z.Z.; Han, X.Q.; Bi, L/P.; Wang, X.B.; Song, P.P.; Kang, Y.Q.; Wang, L.L; Zhang, X.Y.; Wang, Y.B.; Zhang, H. Y*. Gold Nanobipyramid-Mediated Apoptotic Camouflage of Adipocytes for Obesity Immunotherapy. Advanced Materials2022, 34, 2207686
Cheng, Y.; Kong, X. P.; Chang, Y.; Feng, Y. L.; Zheng, R. X.; Wu, X. Q.; Xu, K. Q.; Gao, X. F.; Zhang, H. Y., Spatiotemporally Synchronous Oxygen Self-Supply and Reactive Oxygen Species Production on Z-Scheme Heterostructures for Hypoxic Tumor Therapy. Advanced Materials2020, 32, 1908109.
Cheng, Y.; Chang, Y.; Feng, Y.; Jian, H.; Wu, X.; Zheng, R.; Xu, K.; Zhang, H. Y.*, Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects. Advanced Materials2019, 31, 1806808.
Cheng, Y.; Chang, Y.; Feng, Y. L.; Jian, H.; Tang, Z. H.; Zhang, H. Y.*, Deep-Level Defect Enhanced Photothermal Performance of Bismuth Sulfide-Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging. Angewandte Chemie-International Edition2018, 57, 246-251.
Zhang, H. Y.; Pokhrel, S.; Ji, Z.; Meng, H.; Wang, X.; Lin, S.; Chang, C. H.; Li, L.; Li, R.; Sun, B.; Wang, M.; Liao, Y.-P.; Liu, R.; Xia, T.; Maedler, L.; Nel, A. E.*, Pdo Doping Tunes Band-Gap Energy Levels As Well As Oxidative Stress Responses To A Co3O4 P-Type Semiconductor In Cells And The Lung. Journal of the American Chemical Society 2014, 136, 6406-6420.
Zhang, H. Y.; Dunphy, D. R.; Jiang, X.; Meng, H.; Sun, B.; Tarn, D.; Xue, M.; Wang, X.; Lin, S.; Ji, Z.; Li, R.; Garcia, F. L.; Yang, J.; Kirk, M. L.; Xia, T.; Zink, J. I.; Nel, A.; Brinker, C. J.*, Processing Pathway Dependence Of Amorphous Silica Nanoparticle Toxicity: Colloidal Vs Pyrolytic. Journal of the American Chemical Society 2012, 134, 15790-15804.
Wang, L.; Chang, Y.; Feng, Y.; Li, X.; Cheng, Y.; Jian, H.; Ma, X.; Zheng, R.; Wu, X.; Xu, K.; Zhang, H. Y.*, Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy. Nano Letters2019, 19, 6800.
Liu, X.; Feng, Y.; Xu, G.; Chen, Y.; Luo, Y.; Song, J.; Bao, Y.; Yang, J.; Yu, C.; Li, Y.; Ye, H.; Ke, B.; Chen, B.; Hu, J.; Xu, J.; Meng, H.; Zhang, H. Y.*; Shi, H. *, MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression. Advanced Functional Materials2019, 0, 1806916.
Chang, Y.; Feng, Y.; Cheng, Y.; Zheng, R.; Wu, X.; Jian, H.; Zhang, D.; Tang, Z.; Wang, Z.; Hao, J.; Zhang, H. Y.*, Anisotropic Plasmonic Metal Heterostructures as Theranostic Nanosystems for Near Infrared Light-Activated Fluorescence Amplification and Phototherapy. Advanced Science2019, 6, 1900158.
Liu, N.; Li, K.; Li, X.; Chang, Y.; Feng, Y. L.; Sun, X. J.; Cheng, Y.; Wu, Z. J.; Zhang, H. Y.*, Crystallographic Facet-Induced Toxicological Responses By Faceted Titanium Dioxide Nanocrystals. ACS Nano 2016, 10, 6062-6073.